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Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
The treatment of each peripheral nerve entrapment has its own history, making any single narrative incomplete. [82] Theories on the causes of neuropathic pain have been closely intertwined with surgical research in a feedback loop. Theories of neuropathic pain would inform surgical experimentation, and surgical experimentation would lead to ...
Effective: for diabetic peripheral neuropathic pain (trial: REDUCER) [4] In Japan, the company submitted a marketing application for treatment of peripheral neuropathic pain. [5] The medication was approved for neuropathic pain and postherpetic neuralgia in Japan in January 2019. [6]
Diabetic peripheral neuropathy can be diagnosed with a history and physical examination. The diagnosis is considered in people who develop pain or numbness in a leg or foot with a history of diabetes. Muscle weakness, pain, balance loss, and lower limb dysfunction are the most common clinical manifestations. [7]
Recent studies have demonstrated that electrical stimulation of nerves leads to inhibitory input to the pain pathways at the spinal cord level. [7] PNS is most effective in the treatment of neuropathic pain (e.g., posttraumatic neuropathy, diabetic neuropathy) when the nerve lesion is distal to the site of stimulation. [8]
For neuropathic pain, clinicians look for an underlying lesion to the nervous system or an inciting cause consistent with the development of neuropathic pain. The obvious presence of an underlying feature or cause is not always detectable, and response to treatment may be used as a surrogate particularly in cases where diagnosis of the ...
Central pain syndrome, also known as central neuropathic pain, [1] is a neurological condition consisting of constant moderate to severe pain due to damage to the central nervous system (CNS) which causes a sensitization of the pain system. [2] [3] The extent of pain and the areas affected are related to the cause of the injury. [4]
Gabapentin is recommended as a first-line treatment for chronic neuropathic pain by various medical authorities. [10] [11] [31] [32] This is a general recommendation applicable to all neuropathic pain syndromes except for trigeminal neuralgia, where it may be used as a second- or third-line agent. [11] [32]