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Transglutaminase is also used in molecular gastronomy to meld new textures with existing tastes. Besides these mainstream uses, transglutaminase has been used to create some unusual foods. British chef Heston Blumenthal is credited with the introduction of transglutaminase into modern cooking.
Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme ... Example structure of targeted conditional mutant allele for this gene
Factor XIII is a transglutaminase that circulates in human blood as a heterotetramer of two A and two B subunits. Factor XIII binds to the clot via their B units. In the presence of fibrins, thrombin efficiently cleaves the R37–G38 peptide bond of each A unit within a XIII tetramer.
While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis.
A deficiency is associated with ichthyosis lamellaris. [11] Epidermal transglutaminase is the autoantigen, in humans, of dermatitis herpetiformis.. A study on the mutation of keratinocyte transglutaminase (TGK) came to conclude that those affected with ichthyosis lamellaris, present a substantial deficit in keratinocyte transglutaminase activity. [8]
TGM5 is a transglutaminase enzyme.. TGM5 encodes one member of the multigene transglutaminase family. Transglutaminases (TGs) are involved in protein cross-linking by catalyzing the formation of gamma-glutamyl-lysine isodipeptide bonds between adjacent polypeptides (Candi et al. 2005; Eckert et al. 2005).
The structure of glutaminase has been determined using X-ray diffraction to a resolution of up to 1.73 Å. There are 2 chains containing 305 residues that make up the length of this dimeric protein. On each strand, 23% of the amino acid content, or 71 residues, are found in the 8 helices.
2162 74145 Ensembl ENSG00000124491 ENSMUSG00000039109 UniProt P00488 Q8BH61 RefSeq (mRNA) NM_000129 NM_001166391 NM_028784 RefSeq (protein) NP_000120 NP_001159863 NP_083060 Location (UCSC) Chr 6: 6.14 – 6.32 Mb Chr 13: 37.05 – 37.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Coagulation factor XIII A chain, (FXIIIa) is a protein that in humans is encoded by the F13A1 gene ...