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Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...
Orexin-A is a peptide composed of 33 amino acids including an N-terminal pyroglutamyl residue and two intramolecular disulfide bridges between cysteine residues in 6 and 12 and 7 and 14 positions.
The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX 1 and OX 2 , each encoded by a different gene ( HCRTR1 , HCRTR2 ).
These nutrients are slow to digest, keeping you satisfied for longer and helping regulate your blood sugar levels. This prevents the blood sugar spikes and crashes that often lead to cravings.
Denise Austin is a pro at inspiring women of all ages to live healthy lifestyles with her practical wellness tips and effective “#FitOver50” workout videos. The fitness icon knows many of us ...
A person with an alcohol use disorder, who has gotten used to having a certain level of alcohol in their body every day, can go into withdrawal and experience severe physical symptoms such as ...
In this simplified brain circuit, damage to orexin-secreting neurons in the hypothalamus can lead to inhibition of motor neurons, thus lowering muscle tone.. Cataplexy is considered secondary when it is due to specific lesions in the brain that cause a depletion of the hypocretin neurotransmitter.
Vanlandingham allegedly took a video of the goat and sent it to the animal’s owner, the affidavit claims. The goat died a day later, according to the affidavit, after convulsing and showing ...