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Patiromer was generally well tolerated in studies. Side effects that occurred in more than 2% of patients included in clinical trials were mainly gastro-intestinal problems such as constipation, diarrhea, nausea, and flatulence, and also hypomagnesemia (low levels of magnesium in the blood) in 5% of patients, because patiromer binds magnesium in the gut as well.
Potassium binders are medications that bind potassium ions in the gastrointestinal tract, thereby preventing its intestinal absorption. This category formerly consisted solely of polystyrene sulfonate, a polyanionic resin attached to a cation, administered either orally or by retention enema to patients who are at risk of developing hyperkalaemia (abnormal high serum potassium levels).
They are also used to remove potassium, calcium, and sodium from solutions in technical applications. Common side effects include loss of appetite, gastrointestinal upset, constipation, and low blood calcium. [1] These polymers are derived from polystyrene by the addition of sulfonate functional groups.
Calcium supplements may contribute to the development of kidney stones. [1] Acute calcium poisoning is rare, and difficult to achieve without administering calcium intravenously. For example, the oral median lethal dose (LD 50) for rats for calcium carbonate and calcium chloride are 6.45 [22] and 1.4 g/kg, [23] respectively.
Caltrate contains 600 mg of calcium carbonate as opposed to 200 mg in a typical multivitamin product. Caltrate Plus also contains 800 IU of vitamin D (cholecalciferol), 20 mcg vitamin K1 , 50 mg magnesium , 7.5 mg zinc oxide , 1 mg copper , and 1.8 mg of manganese (II) sulfate monohydrate.
Three studies of Cal/BD topical suspension have evaluated treatment effects on calcium metabolism. In 2 of the 3 trials (n=32 and n=43), elevated urinary calcium levels outside the normal range were observed in 2 patients each. In the third trial (n=109), no clinically relevant changes in urinary calcium were reported. [6]
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Polycarbophil calcium is a drug used as a stool stabilizer. Chemically, it is a synthetic polymer of polyacrylic acid cross-linked with divinyl glycol , with calcium as a counter-ion. Clinical uses
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