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An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]
Enteric coatings are also used for medicines that can be negatively affected by taking a long time to reach the small intestine, where they are absorbed. Coatings are often chosen to control the rate of dissolution of the drug in the gastrointestinal tract. Some drugs are absorbed better in certain parts of the digestive system.
[1] [2] It does not work for poisonings by cyanide, corrosive agents, iron, lithium, alcohols, or malathion. [2] It may be taken by mouth or given by a nasogastric tube. [3] Other uses include inside hemoperfusion machines. [1] Common side effects include vomiting, black stools, diarrhea, and constipation. [1]
Essentially, the capsule consists of extremely small enteric-coated granules (pellets) of the esomeprazole formulation inside an outer shell. When the capsule is immersed in an aqueous solution, as happens when the capsule reaches the stomach, water enters the capsule by osmosis .
Aqueous film coating is the most common film coating method currently used. [1] This type of film coating uses water to aid in the film coating process instead of organic solvents. [1] The result is a safer means of film coating, as it avoids the toxic and flammable properties of organic solvents.
Erythromycin is easily inactivated by gastric acid; therefore, all orally administered formulations are given as either enteric-coated or more-stable salts or esters, such as erythromycin ethylsuccinate. Erythromycin is very rapidly absorbed, and diffuses into most tissues and phagocytes.
Enteric coating on aspirin may be used in manufacturing to prevent release of aspirin into the stomach to reduce gastric harm, but enteric coating does not reduce gastrointestinal bleeding risk. [188] [189] Enteric-coated aspirin may not be as effective at reducing blood clot risk.
Enteric-coated tablets – Epilim EC200 by Sanofi is a 200 mg sodium valproate enteric-coated tablet. UK only. Capsules – Episenta prolonged release by Beacon; ...