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Anti-cancer monoclonal antibodies can be targeted against malignant cells by several mechanisms. Ramucirumab is a recombinant human monoclonal antibody and is used in the treatment of advanced malignancies. [18] In childhood lymphoma, phase I and II studies have found a positive effect of using antibody therapy. [19]
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
The nomenclature of monoclonal antibodies is a naming scheme for assigning generic, or nonproprietary, names to monoclonal antibodies. An antibody is a protein that is produced in B cells and used by the immune system of humans and other vertebrate animals to identify a specific foreign object like a bacterium or a virus .
A general representation of the method used to produce monoclonal antibodies [1] [2] A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell.
Bi-specific T-cell engager (BiTE) is a class of artificial bispecific monoclonal antibodies that are investigated for use as anti-cancer drugs. They direct a host's immune system, more specifically the T cells ' cytotoxic activity, against cancer cells.
Pages in category "Monoclonal antibodies" The following 200 pages are in this category, out of approximately 307 total. This list may not reflect recent changes .
Immunoconjugates are antibodies conjugated (joined) to a second molecule, usually a toxin, radioisotope or label. [1] These conjugates are used in immunotherapy [citation needed] and to develop monoclonal antibody therapy as a targeted form of chemotherapy [2] when they are often known as antibody-drug conjugates.
Toggle L01F Monoclonal antibodies and antibody drug conjugates subsection 6.1 L01FA CD20 (clusters of differentiation 20) inhibitors 6.2 L01FB CD22 (clusters of differentiation 22) inhibitors