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The ligase chain reaction (LCR) is a method of DNA amplification. The ligase chain reaction (LCR) is an amplification process that differs from polymerase chain reaction (PCR) in that it involves a thermostable ligase to join two probes or other molecules together which can then be amplified by standard PCR cycling. [ 1 ]
A locus control region (LCR) is a long-range cis-regulatory element that enhances expression of linked genes at distal chromatin sites. It functions in a copy number-dependent manner and is tissue-specific, as seen in the selective expression of β-globin genes in erythroid cells . [ 1 ]
Furthermore, the union or intersection of the results of the search on a query sequence can be obtained. A Neural Network webserver, named LCR-hound has been developed to predict the function of prokaryotic and eukaryotic LCRs, based on their amino acid or di-amino acid content. [20]
Multiplex ligation-dependent probe amplification was invented by Jan Schouten, a Dutch scientist. [1] The method was first described in 2002 in the scientific journal Nucleic Acid Research . [ 2 ] The first applications included the detection of exon deletions in the human genes BRCA1 , MSH2 and MLH1 , which are linked to hereditary breast and ...
Low complexity regions in proteins can be computationally detected from sequence using various methods and definitions, as reviewed in. [2] Among the most popular methodologies to identify LCRs is by measuring their Shannon entropy. [1] The lower the value of the calculated entropy, the more homogeneous the region is in terms of amino acid content.
As it refers to the product of an amplification reaction, amplicon is used interchangeably with common laboratory terms, such as "PCR product." Artificial amplification is used in research , [ 1 ] forensics , [ 2 ] and medicine [ 1 ] for purposes that include detection and quantification of infectious agents , [ 3 ] identification of human ...
Indiana (11-1) The Hoosiers’ 66-0 win against Purdue put an exclamation point on the best regular season in program history. It also sealed the deal for Indiana to be an at-large team.
Laboratory quality control is designed to detect, reduce, and correct deficiencies in a laboratory's internal analytical process prior to the release of patient results, in order to improve the quality of the results reported by the laboratory.