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Sambrook is best known for his studies on DNA tumor viruses and the molecular biology of normal and neoplastic cells.His Tumour Virus Group at Cold Spring Harbor identified and mapped all of the major genes of adenoviruses and SV40, determined their transcriptional control in infected and transformed cells, and elucidated the mechanism of integration of these viruses into the genome of the ...
While an assistant professor of Biochemistry and Molecular Biology at Harvard, and a member of the Cold Spring Harbor Laboratory (CSHL) faculty, Maniatis collaborated with Drs. Fotis Kafatos and Argiris Efstratiadis to develop a method for synthesizing and cloning full length double stranded DNA copies of messenger RNA (termed “copy” or cDNA).
Cold Spring Harbor Protocols (formerly CSH Protocols) is an online scientific journal and methods database for biologists, published by Cold Spring Harbor Laboratory Press. Protocols are presented step-by-step and edited in the style that has made Molecular Cloning, Antibodies, Cells and many other CSH manuals essential [ tone ] to the work of ...
The Cold Spring Harbor Library & Environmental Center is located at Cold Spring Harbor in Suffolk County, New York. It was founded as the Cold Spring Harbor Village Improvement Society in 1899. However, the library, consisting of a small collection of books, was first organized in 1886 and was housed at the Cutting House, 241 Harbor Road, Cold ...
The choice of vector for molecular cloning depends on the choice of host organism, the size of the DNA to be cloned, and whether and how the foreign DNA is to be expressed. [7] The DNA segments can be combined by using a variety of methods, such as restriction enzyme/ligase cloning or Gibson assembly. [citation needed]
Cold Spring Harbor Laboratory. Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, plant biology, genomics, and quantitative biology. [2] It is located in Laurel Hollow on Long Island, New York.
Michael Howard Wigler (born September 3, 1947, in New York) is an American molecular biologist who has directed a laboratory at Cold Spring Harbor Laboratory since 1978 and is a member of the National Academy of Sciences. He is best known for developing methods to genetically engineer animal cells and his contributions to cancer, genomics and ...
In May 1986 Mullis presented PCR at the Cold Spring Harbor Symposium, [21] and published a modified version of his original 'idea' manuscript much later. [22] The first non-Cetus report using PCR was submitted on September 5, 1986 , [ 23 ] indicating how quickly other laboratories began implementing the technique.
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