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Central hypoventilation syndrome (CHS) is a sleep-related breathing disorder that causes ineffective breathing, apnea, or respiratory arrest during sleep (and during wakefulness in severe cases). CHS can either be congenital (CCHS) or acquired (ACHS) later in life.
The treatment for concentral hypoventilation syndrome involves breathing support during sleep, often through the assistance of a mechanical ventilator. In some cases, this type of breathing support may be necessary during waking hours as well. Often referred to as oxygen therapy, it can use a CPAP machine as well.
The conditions of hypoxia and hypercapnia, whether caused by apnea or not, trigger additional effects on the body.The immediate effects of central sleep apnea on the body depend on how long the failure to breathe endures, how short is the interval between failures to breathe, and the presence or absence of independent conditions whose effects amplify those of an apneic episode.
Central sleep apnea. There are two main mechanism that drive the disease process of CSA, sleep-related hypoventilation and post-hyperventilation hypocapnia. [18] The most common cause of CSA is post-hyperventilation hypocapnia secondary to heart failure. [18]
People with neuromuscular disorders or hypoventilation syndromes involving failed respiratory drive experience central hypoventilation. The most common treatment for this form is the use of non-invasive ventilation such as a bilevel positive airway pressure (BPAP) machine.
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As a side effect of medicines or recreational drugs, hypoventilation may become potentially life-threatening.Many different central nervous system (CNS) depressant drugs such as ethanol, benzodiazepines, barbiturates, GHB, sedatives, and opioids produce respiratory depression when taken in large or excessive doses, or mixed with other depressants.
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