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77782 Ensembl ENSG00000051341 ENSMUSG00000034206 UniProt O75417 Q8CGS6 RefSeq (mRNA) NM_199420 NM_006596 NM_001159369 NM_029977 RefSeq (protein) NP_955452 NP_001152841 NP_084253 Location (UCSC) Chr 3: 121.43 – 121.55 Mb Chr 16: 36.83 – 36.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene. This ...
Microhomology-mediated end joining (MMEJ), also known as alternative nonhomologous end-joining (Alt-NHEJ) is one of the pathways for repairing double-strand breaks in DNA. As reviewed by McVey and Lee, [1] the foremost distinguishing property of MMEJ is the use of microhomologous sequences during the alignment of broken ends before joining, thereby resulting in deletions flanking the original ...
DNA polymerase II (also known as DNA Pol II or Pol II) is a prokaryotic DNA-dependent DNA polymerase encoded by the PolB gene. [1] DNA Polymerase II is an 89.9-kDa protein and is a member of the B family of DNA polymerases. It was originally isolated by Thomas Kornberg in 1970, and characterized over the next few years.
DNA polymerase's ability to slide along the DNA template allows increased processivity. There is a dramatic increase in processivity at the replication fork. This increase is facilitated by the DNA polymerase's association with proteins known as the sliding DNA clamp. The clamps are multiple protein subunits associated in the shape of a ring.
[42] [43] [44] KOD polymerase and some modified thermostable DNA polymerases (iProof/Phusion, Pfu Ultra, Velocity or Z-Taq) are used as a PCR variant with shorter amplification cycles (fast PCR, high-speed PCR) due to their high synthesis rate. Processivity describes the average number of base pairs before a polymerase falls off the DNA template.
POLG is located on the q arm of chromosome 15 in position 26.1 and has 23 exons.The POLG gene produces a 140 kDa protein composed of 1239 amino acids. [7] [8] POLG, the protein encoded by this gene, is a member of the DNA polymerase type-A family.
DNA polymerase epsilon is a member of the DNA polymerase family of enzymes found in eukaryotes. It is composed of the following four subunits: POLE (central catalytic unit), POLE2 (subunit 2), POLE3 (subunit 3), and POLE4 (subunit 4). Recent evidence suggests that it plays a major role in leading strand DNA synthesis and nucleotide and base ...
The crystal structure of pol λ shows that, unlike the DNA polymerases that catalyze DNA replication, pol λ makes extensive contacts with the 5' phosphate of the downstream DNA strand. This allows the polymerase to stabilize the two ends of a double-strand break and explains how pol λ is uniquely suited for a role in non-homologous end joining.
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