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  2. Insulin-like growth factor - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor

    The IGF-1 receptor is the "physiological" receptor. IGF-1 binds to it at significantly higher affinity than it binds the insulin receptor. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase—meaning the receptor signals by causing the addition of a phosphate molecule on particular tyrosines. The IGF-2 receptor only ...

  3. Insulin-like growth factor 1 - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor_1

    Low IGF-1 levels are shown to increase the risk of developing type 2 diabetes and insulin resistance. [67] On the other hand, a high IGF-1 bioavailability in people with diabetes may delay or prevent diabetes-associated complications, as it improves impaired small blood vessel function. [67] IGF-1 has been characterized as an insulin sensitizer ...

  4. Insulin-like growth factor 2 - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor_2

    IGF-2 exerts its effects by binding to the IGF-1 receptor and to the short isoform of the insulin receptor (IR-A or exon 11-). [9] IGF-2 may also bind to the IGF-2 receptor (also called the cation-independent mannose 6-phosphate receptor), which acts as a signalling antagonist; that is, to prevent IGF-2 responses.

  5. Insulin-like growth factor 1 receptor - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor...

    The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1 ...

  6. Insulin-like growth factor-binding protein - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor...

    Approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1.

  7. Insulin-like growth factor 2 receptor - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor...

    Insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is encoded by the IGF2R gene. [ 5 ] [ 6 ] IGF2R is a multifunctional protein receptor that binds insulin-like growth factor 2 (IGF2) at the cell surface and mannose-6-phosphate (M6P)-tagged proteins ...

  8. Growth factor - Wikipedia

    en.wikipedia.org/wiki/Growth_factor

    Insulin-like growth factor-1 (IGF-1) Insulin-like growth factor-2 (IGF-2) Interleukins IL-1- Cofactor for IL-3 and IL-6. Activates T cells. IL-2 – T-cell growth factor. Stimulates IL-1 synthesis. Activates B-cells and NK cells. IL-3 – Stimulates production of all non-lymphoid cells.

  9. CJC-1295 - Wikipedia

    en.wikipedia.org/wiki/CJC-1295

    CJC-1295 may markedly increase plasma growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in animals and humans. [1] [2] [3] [5] With a single injection, in human subjects, CJC-1295 DAC may increase plasma GH levels by 2- to 10-fold for 6 days or longer and plasma IGF-1 levels by 0.5- to 3-fold for 9 to 11 days. [3]

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