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2. Methylene blue - Wikipedia

   en.wikipedia.org/wiki/Methylene_blue

   Methylene blue has been described as "the first fully synthetic drug used in medicine." Methylene blue was first prepared in 1876 by German chemist Heinrich Caro. [69] Its use in the treatment of malaria was pioneered by Paul Guttmann and Paul Ehrlich in 1891. During this period before the first World War, researchers like Ehrlich believed that ...

3. Septic shock - Wikipedia

   en.wikipedia.org/wiki/Septic_shock

   [23] [24] Its mechanism of action is thought to be via the inhibition of the nitric oxide-cyclic guanosine monophosphate pathway. [25] This pathway is excessively activated in septic shock. Methylene blue has been found to work in cases resistant to the usual agents. [26] This effect was first reported in the early 1990s. [27] [28]

4. Methemoglobinemia - Wikipedia

   en.wikipedia.org/wiki/Methemoglobinemia

   Methylene blue is given as a 1% solution (10 mg/ml) 1 to 2 mg/kg administered intravenously slowly over five minutes. Although the response is usually rapid, the dose may be repeated in one hour if the level of methemoglobin is still high one hour after the initial infusion. Methylene blue inhibits monoamine oxidase, and serotonin toxicity can ...

5. Sodium nitrite - Wikipedia

   en.wikipedia.org/wiki/Sodium_nitrite

   Above 330 °C sodium nitrite decomposes (in air) to sodium oxide, nitric oxide and nitrogen dioxide. [88] 2 NaNO 2 → Na 2 O + NO + NO 2. Sodium nitrite can also be used in the production of nitrous acid: 2 NaNO 2 + H 2 SO 4 → 2 HNO 2 + Na 2 SO 4. The nitrous acid then, under normal conditions, decomposes: 2 HNO 2 → NO 2 + NO + H 2 O

6. Why Athletes Love Nitric Oxide Supplements For A Workout ...

   www.aol.com/why-athletes-love-nitric-oxide...

   What is nitric oxide? At a basic level, “nitric oxide is a naturally-occurring gas formed by the combination of nitrogen and oxygen,” says Keri Gans, RD , author of The Small Change Diet .

7. Do Nitric Oxide Supplements Really Help With ED? - AOL

   www.aol.com/nitric-oxide-supplements-really-help...

   Alternatives to Nitric Oxide for ED. Nitric oxide supplements may work, but if you're looking for more proven ED treatments, options abound to improve blood flow. Medications approved by the FDA ...