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Osaterone acetate is an antiandrogen, and hence is an antagonist of the androgen receptor, the biological target of androgens like testosterone and dihydrotestosterone. [3] It is also a progestin, or a synthetic progestogen , and hence is an agonist of the progesterone receptor , the biological target of progestogens like progesterone .
Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.
The medication is available as a component of the veterinary drug Deposterona, which is marketed in Mexico and also contains testosterone acetate and testosterone undecanoate. [1] Testosterone valerate is a short-to-medium duration ester of testosterone, with an elimination half-life of approximately twice that of the short-acting testosterone ...
The male hormone, testosterone, is produced in limited quantities following treatment with Zeuterin, but after two years, testosterone production is similar to that in untreated dogs. [1] The continuing presence of testosterone means that, unlike surgical castration, chemical castration does not remove the risk of testosterone-associated ...
Testosterone promotes prostate cell proliferation, [26] but relatively low levels of serum testosterone are found in patients with BPH. [ 27 ] [ 28 ] One small study has shown that medical castration lowers the serum and prostate hormone levels unevenly, having less effect on testosterone and dihydrotestosterone levels in the prostate.
Delmadinone acetate (DMA), sold under the brand name Tardak among others, is a progestin and antiandrogen which is used in veterinary medicine to treat androgen-dependent conditions such as benign prostatic hyperplasia.
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Most dominantly aggressive dogs are male, which causes many people to neuter their male canine companions. Removing testosterone can decrease the intensity of a canine's reaction to stimulus. Testosterone does not cause a behavior to occur, but its absence may decrease the occurrence of a "bad" behavior. [60]