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Side effects of spironolactone which may be indicative of hyperkalemia and if persistent could justify serum potassium testing include nausea, fatigue, and particularly muscle weakness. [63] Notably, non-use of routine potassium monitoring with spironolactone in young women would reduce costs associated with its use. [63]
Spironolactone has shown no significant effect on levels of testosterone, estradiol, luteinizing hormone, and follicle-stimulating hormone in men. [ 146 ] [ 78 ] No or only small changes in cortisol levels have been observed in clinical studies with spironolactone.
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
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Spironolactone is an acne treatment prescribed by dermatologists. Find out how spironolactone improves the appearance of hormonal acne, side effects, and more. Everything I Wish I Knew About ...
On the other hand, most [bio]identical hormone replacement therapy is absorbed across the skin, [and thus] avoids being metabolized in the liver, and tends to have less of a platelet aggregation ...
Spirolactones are a class of functional group in organic chemistry featuring a cyclic ester attached spiro to another ring system. The name is also used to refer to a class of synthetic steroids, called steroid-17α-spirolactones, 17α-spirolactosteroids, or simply 17α-spirolactones, which feature their spirolactone group at the C17α position.
Estrogen, alongside other hormones, works to optimize the efficiency of your bodily functions. But an imbalance in hormones — like low estrogen levels — can affect many things, from your drive ...