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The Age-Related Eye Disease Study (AREDS) was a clinical trial sponsored by the National Eye Institute that ran from 1992 to 2001. [1] The study was designed to: investigate the natural history and risk factors of age-related macular degeneration (AMD) and cataracts , and
The specific vitamins and minerals in AREDS-1 are vitamin C (500 mg), zinc (80 mg), vitamin E (400 IU), copper (2 mg) and beta-carotene (15 mg). In the AREDS-2 formulation, lutein (10 mg) and zeaxanthin (2 mg) replaced beta-carotene due to the risk of lung cancer in smokers taking beta-carotene. [ 2 ]
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Age-Related Eye Disease Study 2 (AREDS2): This study investigated the roles of zinc and beta-carotene in the original AREDS formulation. It also examined whether adding omega-3 fatty acids and the antioxidants lutein and zeaxanthin would improve the effectiveness of the AREDS formulation. [10]
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