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[122] [126] High doses or levels of AAS, including testosterone, can cause polycythemia—high red blood cell and/or hemoglobin levels that increase the risk of stroke—as an adverse effect. [ 121 ] [ 122 ] Conversely, whether via castration, NSAA monotherapy, or CAB , decreased erythropoiesis resulting in mild anemia is a common side effect ...
There may be an increase in heart disease if HRT is given twenty years post-menopause. [44] This variability has led some reviews to suggest an absence of significant effect on morbidity. [45] Importantly, there is no difference in long-term mortality from HRT, regardless of age. [46]
The compensatory constriction of the arteries and increased heart rate can cause blood pressure to overshoot normal values, triggering the opposite baroreflex. This time, the brain increases parasympathetic signalling and decreases sympathetic signalling, causing a decrease in heart rate (the turbulence slope part of HRT).
[10] [96] In accordance, estradiol, at typical menopausal replacement dosages, has been found not to increase the risk of blood clots or insulin resistance, [118] [12] nor to affect hepatic SHBG, IGF-1, GHBP, [119] IGFBP, [120] and other protein production and by extension circulating hepatic protein levels.
Hormone replacement therapy (HRT), also known as menopausal hormone therapy (MHT), is for women with menopausal symptoms. It is based on the idea that the treatment may prevent discomfort caused by diminished circulating estrogen and progesterone hormones, or in the case of the surgically or prematurely menopausal, that it may prolong life and may reduce incidence of dementia. [1]
Risks associated with the less-controlled process of compounding bioidentical hormones are not clearly understood. In addition, the accuracy and efficacy of saliva testing have not been definitively proven, and the long-term effects of using blood testing to reach target levels of hormones have not been researched.
Estradiol (E2) is a medication and naturally occurring steroid hormone. [11] [12] [13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women.
Chronotropic effects (from chrono-, meaning time, and tropos, "a turn") are those that change the heart rate. Chronotropic drugs may change the heart rate and rhythm by affecting the electrical conduction system of the heart and the nerves that influence it , such as by changing the rhythm produced by the sinoatrial node .
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