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Loeys–Dietz syndrome can cause cleft palate or bifid uvula, hypertelorism, and aortic aneurysm. [42] Hardikar syndrome can cause cleft lip and palate, Hydronephrosis, Intestinal obstruction and other symptoms. [43] Cleft lip/palate may be present in many different chromosome disorders including Patau syndrome (trisomy 13).
Maxillary hypoplasia is the most common secondary deformity that results from cleft lip and cleft palate. Because of the subjective nature of the diagnosis, the incidence of maxillary hypoplasia in people with cleft lip and palate varies between 15-50%. It is estimated that 25-50% of these patients require surgical intervention. [7]
A cleft palate is one of the most common causes of VPI. Cleft palate is an anatomical abnormality that occurs in utero and is present at birth. This malformation can affect the lip and palate, or the palate only. A cleft palate can affect the mobility of the velopharyngeal valve, thereby resulting in VPI. [citation needed]
Holoprosencephaly-ectrodactyly-cleft lip/palate syndrome; Other names: Hartsfield syndrome [1] Specialty: Medical genetics: Diagnostic method: genetic testing, physical examination: Prevention: None: Prognosis: poor: Frequency: rare, about 35 cases have been described in the medical literature: Deaths: most patients are either stillborn or die ...
Furthermore, if a cleft patient has lip pits, he or she has a ten times greater risk of having a child with cleft lip with or without cleft palate than a cleft patient who does not have lip pits. [4] Types of clefting between parents and affected children are significantly associated; however, different types of clefts may occur horizontally ...
In patients with cleft palate, the palate must be repaired through a palatoplasty for normal velopharyngeal function. Despite the palatoplasty, 20-30% of these patients will still have some degree of velopharyngeal insufficiency, which will require surgical (or prosthetic) management for correction. Therefore, a secondary operation is necessary ...
Treatment of Roberts syndrome is individualized and specifically aimed at improving the quality of life for those afflicted with the disorder. Some of the possible treatments include: surgery for the cleft lip and palate, correction of limb abnormalities (also through surgery), and improvement in prehensile hand grasp development. [3]
The palate may be arched excessively (a high palate), because the tongue does not form a suction that would normally shape the palate down further. The palate may have a groove (this may be partially due to intubation early on if it is for an extended period of time) or may be cleft (incompletely formed).