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Conditional gene knockout is a technique used to eliminate a specific gene in a certain tissue, such as the liver. [1] [2] This technique is useful to study the role of individual genes in living organisms. It differs from traditional gene knockout because it targets specific genes at specific times rather than being deleted from beginning of life.
The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse embryonic stem cell lines that together lack every gene in the genome, and then to distribute the cells to scientific researchers to create knockout mice to study.
Ron DePinho's group generated Foxo3 knockout mice, and showed that female exhibit a dramatic age-dependent infertility, due to premature ovarian failure. Gopinath et al ., found that FOXO3 promotes quiescence of muscle stem cells during self-renewal in a Notch-dependent mechanism using muscle stem cell-specific conditional knock out mice. <Stem ...
The mutations introduced in the ES Cells are conditional: this means that the initial mutation can be modified - by the application of particular DNA-altering enzymes (site specific recombinases) to make the knockout initially latent in the genome. The gene can be later knocked out (inactivated) at a specific time-point or tissue-type in mutant ...
Examples of research in which knockout mice have been useful include studying and modeling different kinds of cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson's disease. Knockout mice also offer a biological and scientific context in which drugs and other therapies can be developed and tested.
CBP and p300 are critical for normal embryonic development, as mice completely lacking either CBP or p300 protein, die at an early embryonic stage. [ 17 ] [ 18 ] In addition, mice which lack one functional copy ( allele ) of both the CBP and p300 genes (i.e. are heterozygous for both CBP and p300) and thus have half of the normal amount of both ...
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