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Permethrin is a medication and an insecticide. [6] [7] As a medication, it is used to treat scabies and lice. [8]It is applied to the skin as a cream or lotion. [6] As an insecticide, it can be sprayed onto outer clothing or mosquito nets to kill the insects that touch them.
Cypermethrin is moderately toxic through skin contact or ingestion. It may cause irritation to the skin and eyes. Symptoms of dermal exposure include numbness, tingling, itching, burning sensation, loss of bladder control, incoordination, seizures and possible death.
[10] Benzyl benzoate can be a skin irritant when used as a topical scabicide. [7] Overdose can result in blistering and hives or a rash can occur as an allergic reaction. [12] [13] As an excipient in some testosterone-replacement injectable medications, benzyl benzoate has been reported as a cause of anaphylaxis in a case in Australia. [14]
A separate review found that although oral ivermectin is usually effective for the treatment of scabies, it does have a higher treatment failure rate than topical permethrin. [49] Another review found that oral ivermectin provided a reasonable balance between efficacy and safety. [50]
Consumer Reports retests in 2006 gave as result that a 7% solution of icaridin offered little or no protection against Aedes mosquitoes (vector of dengue fever) and a protection time of about 2.5 hours against Culex (vector of West Nile virus), while a 15% solution was good for about one hour against Aedes and 4.8 hours against Culex. [17]
DEET is effective against a variety of invertebrates, including ticks, flies, mosquitos, and some parasitic worms. [3]A 2018 systematic review found no consistent performance difference between DEET and icaridin in field studies and concluded that they are equally preferred mosquito repellents, noting that 50% DEET offers longer protection but is not available in some countries.
Bifenthrin is poorly soluble in water and often remains in soil. Its residual half-life in soil is between 7 days and 8 months, depending on the soil type, with a low mobility in most soil types. Bifenthrin has the longest known residual time in soil of insecticides currently on the market. It is a white, waxy solid with a faint sweet smell.
According to the German Patent bureau, the industrial synthesis of diazinon is as follows: β-isobutyrylaminocrotonic acid amine was cyclized with NaOR (R is either a hydrogen or aliphatic chain of 1 to 8 carbons) in a mixture of 0 to 100% by weight of water and an alcohol having 1 to 8 carbon atoms, above 90°C (but below the boiling point of the mixture used).
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