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In enzymology, a phosphate acetyltransferase (EC 2.3.1.8) is an enzyme that catalyzes the chemical reaction acetyl-CoA + phosphate ⇌ {\displaystyle \rightleftharpoons } CoA + acetyl phosphate The substrates of this enzyme are acetyl-CoA and phosphate , whereas its two products are CoA and acetyl phosphate .
Mevalonate pathway diagram showing the conversion of acetyl-CoA into isopentenyl pyrophosphate, the essential building block of all isoprenoids. The eukaryotic variant is shown in black. Archaeal variants are shown in red and blue.
In enzymology, an acetate kinase (diphosphate) (EC 2.7.2.12) is an enzyme that catalyzes the chemical reaction. diphosphate + acetate phosphate + acetyl phosphate. Thus, the two substrates of this enzyme are diphosphate and acetate, whereas its two products are phosphate and acetyl phosphate.
Glucose availability affects the intracellular pool of acetyl-CoA, a central metabolic intermediate that is also the acetyl donor in histone acetylation. Glucose is converted to acetyl-CoA by the pyruvate dehydrogenase complex (PDC), which produces acetyl-CoA from glucose-derived pyruvate; and by adenosine triphosphate-citrate lyase (ACLY ...
The 4 substrates of this enzyme are acetyl phosphate, NH 3, thioredoxin disulfide, and H 2 O, whereas its 3 products are glycine, phosphate, and thioredoxin. This enzyme belongs to the family of oxidoreductases , to be specific, those acting on X-H and Y-H to form an X-Y bond with a disulfide as acceptor.
In addition, acetyl-CoA is a precursor for the biosynthesis of various acetyl-chemicals, acting as an intermediate to transfer an acetyl group during the biosynthesis of those acetyl-chemicals. Acetyl-CoA is also involved in the regulation of various cellular mechanisms by providing acetyl groups to target amino acid residues for post ...
The systematic name is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase , phosphopyruvate dehydrogenase phosphatase , [pyruvate dehydrogenase (lipoamide)]-phosphatase , and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase .
Acetyl phosphate (AcP), a precursor to ATP, can readily be synthesized at modest yields from thioacetate in pH 7 and 20 °C and pH 8 and 50 °C, although acetyl phosphate is less stable in warmer temperatures and alkaline conditions than in cooler and acidic to neutral conditions.