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Chelation therapy is a medical procedure that involves the administration of chelating agents to remove heavy metals from the body. [1] Chelation therapy has a long history of use in clinical toxicology [2] and remains in use for some very specific medical treatments, although it is administered under very careful medical supervision due to various inherent risks, including the mobilization of ...
Not all heavy metals are particularly toxic, and some are essential, such as iron. The definition may also include trace elements when abnormally high doses may be toxic. An option for treatment of metal poisoning may be chelation therapy, a technique involving the administration of chelation agents to remove metals from the body.
Heavy metal detox, or detoxification, is the removal of toxic heavy metal substances from the body. In conventional medicine, detoxification can also be achieved artificially by techniques such as dialysis and (in a very limited number of cases) chelation therapy. There is a firm scientific base in evidence-based medicine for this treatment. [1]
Chelators can be used in chelation therapy to remove toxic metals in the body. TPEN is a chelator that has a high affinity for zinc. TPEN is a chelator that has a high affinity for zinc. For example, one study showed that TPEN is a stronger chelator compared to other chelators like pentetic acid (DTPA) when high levels of zinc are present (15 μM).
Cadmium is a naturally occurring toxic metal with common exposure in industrial workplaces, plant soils, and from smoking. Due to its low permissible exposure in humans, overexposure may occur even in situations where only trace quantities of cadmium are found.
2,3-Dimercapto-1-propanesulfonic acid (abbreviated DMPS) and its sodium salt (known as Unithiol) are chelating agents that form complexes with various heavy metals. They are related to dimercaprol, which is another chelating agent. The synthesis of DMPS was first reported in 1956 by V. E. Petrunkin. [2]
Metals have been used in treatments since ancient times. The Ebers Papyrus from 1500BC is the first written account of the use of metals for treatment and describes the use of Copper to reduce inflammation and the use of iron to treat anemia. Sodium vanadate has been used since the early 20th century to treat rheumatoid arthritis.
For biological effects of substances such as radioactive iodine the ingestion of non-radioactive isotopes may substantially reduce the biological uptake of the radioactive form, and chelation therapy may be applied to accelerate the removal of radioactive materials formed from heavy metals from the body by natural processes.
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