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Lokivetmab, trade name Cytopoint, is a monoclonal antibody used to treat atopic dermatitis in dogs. [1] It acts against interleukin 31 (IL-31), [2] which is a cytokine involved in causing itchiness (pruritus). [2] Lokivetmab is administered by subcutaneous injection; each dose is effective for four to eight weeks. [3]
Therapeutic, diagnostic and preventive monoclonal antibodies are clones of a single parent cell. When used as drugs, the International Nonproprietary Names (INNs) end in -mab.
[20] [21] IL-31 is a key cytokine at the pruritogenic receptors at neurons near the skin, and also induces peripheral blood mononuclear cells and keratinocytes to release pro-inflammatory cytokines. [16] Suppression of IL-4 and IL-13 causes a decrease of T h 2-cell differentiation, which plays a role in atopic dermatitis. [19]
76399 Ensembl ENSG00000204671 ENSMUSG00000029437 UniProt Q6EBC2 Q6EAL8 RefSeq (mRNA) NM_001014336 NM_029594 RefSeq (protein) NP_001014358 NP_083870 Location (UCSC) Chr 12: 122.17 – 122.17 Mb Chr 5: 123.62 – 123.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene that resides on chromosome 12. IL-31 is ...
Employees have until Thursday to decide whether to accept the offer, which the White House hopes will reduce the federal payroll by between 5% and 10%.
You've likely seen warnings against taking aspirin as a preventative measure against heart attack and stroke. It isn't quite that simple.
Tim (Franco) and Millie (Brie) have been together for 10 years, and still love each other, but they have enough problems that their relationship has curdled into a habitual “what are we doing ...
Methylprednisolone suleptanate, sold under the brand names Medrosol and Promedrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically, the C21 suleptanate 21-(8-(methyl-(2-sulfoethyl)amino)-1,8-dioxooctanoate) ester of methylprednisolone. [1] [2] It acts as a prodrug of methylprednisolone. [3]