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Cystic fibrosis (also known as CF or mucoviscidosis) is an autosomal recessive genetic disorder affecting most critically the lungs, and also the pancreas, liver, and intestine.
It was first isolated in patients with cystic fibrosis (CF) in 1977, when it was known as Pseudomonas cepacia. [21] In the 1980s, outbreaks of B. cepacia in individuals with CF were associated with a 35% death rate. B. cepacia has a large genome, containing twice the amount of genetic material as E. coli. [citation needed]
B. gladioli in humans is an opportunistic pathogen that is an important agent for hospital-associated infections. It has recently appeared as a severe pathogen in patients with cystic fibrosis, causing severe pulmonary infections. [2] Though it is still a fairly uncommon pathogen, its presence is associated with a poor prognosis. It has also ...
Judah, a 14-year-old boy who was diagnosed with cystic fibrosis at just two weeks old has spent his life in and out of the hospital undergoing daily treatments, regular doctor appointments and ...
[3] [9] Infection is sometimes associated with underlying immunodeficiency, including immunoglobulin M deficiency, various cancer chemotherapies, inhaled steroids, surgical procedures, prolonged or broad-spectrum antimicrobial treatment for other infections, [3] and cystic fibrosis. [5] It has also been the cause of hospital-acquired infections ...
Cystic fibrosis is an autosomal recessive genetic disorder of the CFTR protein which reduces chloride and sodium ion transport through the cell membrane, causing thicker than normal mucus secretions. [ 13 ] [ 14 ] The CFTR protein is found in epithelial cells of the lung, liver, pancreas, digestive tract, and reproductive tracts.
The Cystic Fibrosis Foundation, a non-profit organization dedicated to improving healthcare for people with cystic fibrosis, provided $150 million of the funding for the development for ivacaftor in exchange for royalty rights in the event that the medication was successfully developed and commercialized.
It is frequently associated with cystic fibrosis and hospital-acquired infections. [14] Salmonella is a genus of bacteria, known to cause gastrointestinal infections. [15] Staphylococcus aureus is a bacterium known to cause skin infections and sepsis, among other pathologies. Notably, S. aureus has evolved several drug-resistant strains ...
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