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Mestanolone was discovered in 1935 and was introduced for medical use in the 1950s. [6] [7] [8] [4] In addition to its medical use, mestanolone has been used to improve physique and performance. [4] It was used in East Germany in Olympic athletes as part of a state-sponsored doping program in the 1970s and 1980s. [4]
Insulin glargine is a long-acting modified form of medical insulin used in the management of type 1 and type 2 diabetes. [133] It is administered through subcutaneous injection. Its effects typically begin within an hour of injection. [133] Common side effects include (hypoglycemia, issues at the injection site, itchiness, and weight gain. [133]
The main goal of diabetes management is to keep blood glucose (BG) levels as normal as possible. [1] If diabetes is not well controlled, further challenges to health may occur. [1] People with diabetes can measure blood sugar by various methods, such as with a BG meter or a continuous glucose monitor, which monitors over several days. [2]
Metenolone acetate is taken by mouth, while metenolone enanthate is given by injection into muscle. [ 6 ] Side effects of metenolone esters include symptoms of masculinization like acne , increased hair growth , voice changes , and increased sexual desire . [ 6 ]
The American Diabetes Association defines the following criteria for the diagnosis of diabetes: a HbA1c of 6.5%, an 8-hour fasting blood glucose of 7.0 mmol/L (126 mg/dL), a 2-hour oral glucose tolerance test (OGTT) of ≥ 11.1 mmol/L (200 mg/dL), or in patients exhibiting hyperglycemic symptoms, a random plasma glucose of ≥ 11.1 mmol/L (200 mg/dL).
Mesterolone is described as a very poor anabolic agent due to inactivation by 3α-hydroxysteroid dehydrogenase (3α-HSD) in skeletal muscle tissue, similarly to DHT and mestanolone (17α-methyl-DHT). [2] In contrast, testosterone is a very poor substrate for 3α-HSD, and so is not similarly inactivated in skeletal muscle. [2]
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