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Mestanolone was discovered in 1935 and was introduced for medical use in the 1950s. [6] [7] [8] [4] In addition to its medical use, mestanolone has been used to improve physique and performance. [4] It was used in East Germany in Olympic athletes as part of a state-sponsored doping program in the 1970s and 1980s. [4]
Insulin glargine is a long-acting modified form of medical insulin used in the management of type 1 and type 2 diabetes. [133] It is administered through subcutaneous injection. Its effects typically begin within an hour of injection. [133] Common side effects include (hypoglycemia, issues at the injection site, itchiness, and weight gain. [133]
The main goal of diabetes management is to keep blood glucose (BG) levels as normal as possible. [1] If diabetes is not well controlled, further challenges to health may occur. [1] People with diabetes can measure blood sugar by various methods, such as with a BG meter or a continuous glucose monitor, which monitors over several days. [2]
Metenolone acetate is taken by mouth, while metenolone enanthate is given by injection into muscle. [ 6 ] Side effects of metenolone esters include symptoms of masculinization like acne , increased hair growth , voice changes , and increased sexual desire . [ 6 ]
The American Diabetes Association defines the following criteria for the diagnosis of diabetes: a HbA1c of 6.5%, an 8-hour fasting blood glucose of 7.0 mmol/L (126 mg/dL), a 2-hour oral glucose tolerance test (OGTT) of ≥ 11.1 mmol/L (200 mg/dL), or in patients exhibiting hyperglycemic symptoms, a random plasma glucose of ≥ 11.1 mmol/L (200 mg/dL).
Mesterolone is described as a very poor anabolic agent due to inactivation by 3α-hydroxysteroid dehydrogenase (3α-HSD) in skeletal muscle tissue, similarly to DHT and mestanolone (17α-methyl-DHT). [2] In contrast, testosterone is a very poor substrate for 3α-HSD, and so is not similarly inactivated in skeletal muscle. [2]
Alpha-glucosidase inhibitors (AGIs) are oral anti-diabetic drugs used for diabetes mellitus type 2 that work by preventing the digestion of carbohydrates (such as starch and table sugar). They are found in raw plants/herbs such as cinnamon and bacteria (containing the inhibitor acarbose ).
Metenolone enanthate, or methenolone enanthate, sold under the brand names Primobolan Depot and Nibal Injection, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure.
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