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Deamination is the removal of an amino group from a molecule. [1] Enzymes that catalyse this reaction are called deaminases. In the human body, deamination takes place primarily in the liver; however, it can also occur in the kidney. In situations of excess protein intake, deamination is used to break down amino acids for energy.
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 also known as C->U-editing enzyme APOBEC-1 is a protein that in humans is encoded by the APOBEC1 gene. [5]This gene encodes a member of the APOBEC protein family and the cytidine deaminase enzyme family.
Cytosine can also be methylated into 5-methylcytosine by an enzyme called DNA methyltransferase or be methylated and hydroxylated to make 5-hydroxymethylcytosine. The difference in rates of deamination of cytosine and 5-methylcytosine (to uracil and thymine ) forms the basis of bisulfite sequencing .
Activation-induced cytidine deaminase, also known as AICDA, AID and single-stranded DNA cytosine deaminase, is a 24 kDa enzyme which in humans is encoded by the AICDA gene. [5] It creates mutations in DNA [6] [7] by deamination of cytosine base, which turns it into uracil (which is recognized as a thymine). In other words, it changes a C:G base ...
More specifically, the catalytic domain is a zinc dependent cytidine deaminase domain and is essential for cytidine deamination. The positively charged zinc ion in the catalytic domain attracts to the partial-negative charge of RNA. In the case of APOBEC-1, the mRNA transcript of intestinal apolipoprotein B is altered.
72269 Ensembl ENSG00000158825 ENSMUSG00000028755 UniProt P32320 P56389 RefSeq (mRNA) NM_001785 NM_028176 RefSeq (protein) NP_001776 NP_082452 Location (UCSC) Chr 1: 20.59 – 20.62 Mb Chr 4: 138.07 – 138.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene. This gene encodes an enzyme involved in pyrimidine ...
n/a Ensembl ENSG00000128383 ENSG00000262156 n/a UniProt P31941 n/a RefSeq (mRNA) NM_145699 NM_001270406 n/a RefSeq (protein) NP_001257335 NP_663745 n/a Location (UCSC) Chr 22: 38.95 – 38.99 Mb n/a PubMed search n/a Wikidata View/Edit Human Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A, also known as APOBEC3A, or A3A is a gene of the APOBEC3 family found in primates ...
In enzymology, a cytosine deaminase (EC 3.5.4.1) is an enzyme that catalyzes the chemical reaction cytosine + H 2 O ⇌ {\displaystyle \rightleftharpoons } uracil + NH 3 Thus, the two substrates of this enzyme are cytosine [ 1 ] and H 2 O , whereas its two products are uracil and NH 3 .