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The glycosaminoglycan side chains are polyanionic, which causes adjacent side chains to push each other away and create a "bottle brush", where hyaluronic acid is the stem and the side chains are the bristles. When pressure is exerted on the joint, fluids move between the chondrocytes and synovial fluid, exchanging nutrients. [4]
Pentosan polysulfate, like Adequan, has been shown to improve signs of osteoarthritis. In non-equine models, Pentosan has been shown to increase proteoglycan synthesis, [40] stimulate hyaluronic acid production in osteoarthritic joints (a benefit not shared by PSGAGs), [41] reduce inflammatory cytokines, and improve damaged articular cartilage ...
This liquid supplement is a daily, oral version of hyaluronic acid (HA), also called sodium hyaluronate, which had normally been administered by injection. HA is used to promote normal joint function, and to improve joint comfort and performance. LubriSyn is available for horses, humans, and pets. [1]
The most popular of these are joint supplements such as glucosamine, chondroitin, MSM, and hyaluronic acid. Related to joint supplements are various treatments for pain, viewed as alternatives to the common mainstream pain-reducing medications phenylbutazone, and banamine. Another common group of alternative treatments are “calming ...
Hyaluronic acid is a sugar molecule found naturally in our bodies that holds up to 1,000 times its weight in water to keep our skin hydrated and plump.
Other joint medications, like hyaluronic acid and Adequan, may help alleviate the pain if the horse has mild bone spavin. However, they are less useful for treating moderate of severe cases. Nutritional supplements containing MSM, glucosamine, and other ingredients may also help horses with moderate bone spavin.
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