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Download as PDF; Printable version; In other projects ... the ionic selectivity for potassium channels was that the carbonyl ... as the ions move through the free ...
Bertil Hille pioneered the concept of ion channels as membrane proteins forming gated aqueous pores (with Clay Armstrong). [6] [7] He showed that Na+ and K+ channels of axons could be distinguished by drugs such as tetrodotoxin and tetraethylammonium ion, and that their ionic selectivity can be understood by limiting pore size, the selectivity filter, and by movements of ions through a series ...
Download as PDF; Printable version; In other projects Wikidata item; ... A channel modulator, or ion channel modulator, is a type of drug which modulates ion channels.
Voltage-gated ion-channels are usually ion-specific, and channels specific to sodium (Na +), potassium (K +), calcium (Ca 2+), and chloride (Cl −) ions have been identified. [1] The opening and closing of the channels are triggered by changing ion concentration, and hence charge gradient, between the sides of the cell membrane.
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The Hille equation relates the maximum ionic conductance of an ion channel to its length and radius (or diameter), with the commonly used version implicitly takes into account a hemispherical cap. [1]
Voltage-gated proton channels are ion channels that have the unique property of opening with depolarization, but in a strongly pH-sensitive manner. [1] The result is that these channels open only when the electrochemical gradient is outward, such that their opening will only allow protons to leave cells .
Chemical structure and expected channel forming mechanism for the first attempt at preparing a synthetic ion channel [7]. While semi-synthetic ion channels, often based on modified peptidic channels like gramicidin, had been prepared since the 1970s, the first attempt to prepare a synthetic ion channel was made in 1982 using a substituted β-cyclodextrin.