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Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents.It is effective for the treatment of several cancers, including solid tumours of breast, head and neck, lung, bladder, as well as acute lymphocytic leukemias, non-Hodgkin's lymphoma, osteosarcoma, and choriocarcinoma and other trophoblastic neoplasms.
In the UK, patients on methotrexate (MTX) are given a booklet produced by the National Patient Safety Agency and it mentions that there have been problems with patients being given the wrong dosages as the different strength tablets look similar. It notes that some hospitals now only use the 2.5 mg tablets to prevent such problems.
Cyclophosphamide Methotrexate Fluorouracil (CMF) is a commonly used regimen of breast cancer chemotherapy that combines three anti-cancer agents: cyclophosphamide, methotrexate, and 5-fluorouracil (5-FU). [1]
Methotrexate treats cancer, lupus, rheumatoid arthritis, psoriasis but can cause birth defects. Some women can't get it because of abortion laws, fear punishment.
Use of methotrexate together with NSAIDs is safe, if adequate monitoring is done. [151] COX-2 inhibitors, such as celecoxib, and NSAIDs are equally effective. [152] [153] A 2004 Cochrane review found that people preferred NSAIDs over paracetamol. [154] However, it is yet to be clinically determined whether NSAIDs are more effective than ...
The study also evaluated 9 patients (aged 12–31 years, median age 16) treated with methotrexate + vinblastine, methotrexate + vinorelbine, or vinblastine + vinorelbine; 2 patients attained complete responses, 3 attained partial responses, 2 had steady disease, and 2 had progressive disease; this groups' progression-free time was not reached ...
In 1983, Coates et al. found that patients receiving chemotherapy ranked nausea and vomiting as the first and second most severe side effects, respectively. Up to 20% of patients receiving highly emetogenic agents in this era postponed, or even refused, potentially curative treatments. [1]
Many patients receive an NSAID and at least one DMARD, sometimes with low-dose oral glucocorticoids. If disease remission is observed, regular NSAIDs or glucocorticoid treatment may no longer be needed. DMARDs help control arthritis, but do not cure the disease.
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