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Diphenhydramine is a potent anticholinergic agent and potential deliriant in higher doses. This activity is responsible for the side effects of dry mouth and throat, increased heart rate, pupil dilation, urinary retention, constipation, and, at high doses, hallucinations or delirium.
After a later-deleted Facebook post by the teen's family member claimed that the death was the result of a "Benadryl challenge," news outlets reported on the dangers of the supposed social media trend. [33] [34] This prompted the FDA to release a statement on the dangers of high doses of diphenhydramine. [35]
Diphenhydramine was the prototypical agent in this group. Significant anticholinergic adverse effects, as well as sedation, are observed in this group but the incidence of gastrointestinal adverse effects is relatively low. [4] [15] Diphenhydramine; Carbinoxamine; Doxylamine; Orphenadrine; Bromazine; Clemastine; Dimenhydrinate; Alkylamines
The recommended dosage of Benadryl tablets for adults is 1 to 2 tablets every 4 to 6 hours, [1] and only 1 tablet every 4 to 6 hours for children under the age of 12. [2]The Benadryl challenge is an internet challenge that emerged in 2020, revolving around the deliberate consumption, excessive use and overdose of the antihistamine medicine diphenhydramine (commonly sold in the United States ...
The altered state of consciousness produced by common or 'classical' deliriant substances such as scopolamine, atropine and diphenhydramine is mediated through the drug compounds' competitive antagonism of the peripheral and central muscarinic acetylcholine receptors, especially the M 1 muscarinic receptor.
Doxylamine and other first-generation antihistamines are the most widely used sleep medications in the world. [6] Typical side effects of doxylamine (at recommended doses) include dizziness, drowsiness, grogginess, and dry mouth, among others. [7][4] As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor.
Overmedication can have harmful effects, ... (diphenhydramine) was a concern due to use of social media by teenagers in the United States, with the FDA issuing a ...
Mirtazapine (tetracyclic antidepressant, also has antiemetic and appetite-stimulating effects; trade name: Remeron) Olanzapine (atypical antipsychotic; trade name: Zyprexa) Olopatadine (used locally) Orphenadrine (a close relative of diphenhydramine used mainly as a skeletal muscle relaxant and anti-Parkinsons agent)