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The diagnosis is considered in people who develop pain or numbness in a leg or foot with a history of diabetes. Muscle weakness, pain, balance loss, and lower limb dysfunction are the most common clinical manifestations. [7] Physical exam findings may include changes in appearance of the feet, presence of ulceration, and diminished ankle reflexes.
Dysesthesia is commonly seen in diabetic patients, and can be relieved by using creams containing capsaicin. Dysesthesia may be seen in patients with Guillain–Barré syndrome. Dysesthesia is among symptoms of neuropathy (along with paresthesias, gait disturbance, weakness, and absent DTRs).
Diabetes most commonly causes damage to the long nerves that supply the feet and lower legs, causing numbness, tingling and pain (diabetic polyneuropathy). Although these symptoms may also be present, the pain and weakness of proximal diabetic neuropathy often onset more quickly and affect nerves closer to the torso. [citation needed]
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