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Sulfasalazine is used in the treatment of inflammatory bowel disease, including ulcerative colitis and Crohn's disease. It is also indicated for use in rheumatoid arthritis and used in other types of inflammatory arthritis (e.g. psoriatic arthritis and reactive arthritis). [11] [3] [2] It is usually not given to children under two years of age ...
The most commonly prescribed oral steroid is prednisone, which is typically dosed at 0.5 mg/kg for induction of remission in Crohn's disease. [5] Intravenous steroids, administered in a hospital setting, are used when oral steroids do not work or cannot be taken. [ 4 ]
Patients on high dose sulfasalazine require folic supplementation (1 mg/day) because it inhibits folate absorption. If oral Mesalazine is still not working, prednisone is often given, starting at 40–60 mg/day. Prednisone often takes effect within 10–14 days. The dose should then be tapered by about 5 mg/week until it can be stopped altogether.
An aminosalicylate is a class of medications that is often used to treat ulcerative colitis [1] and Crohn's disease. The class includes among others: [1] 4-Aminosalicylic acid; Balsalazide; Olsalazine; Sulfasalazine; Mesalazine (5-Aminosalicylic acid) Side effects may include abdominal pain, diarrhea, headaches, and nausea. [1]
Crohn's disease may be similar in appearance, a fact that can make diagnosing UC a challenge. H&E stain of a colonic biopsy showing a crypt abscess, a classic finding in ulcerative colitis The initial diagnostic workup for ulcerative colitis consists of a complete history and physical examination, assessment of signs and symptoms, laboratory ...
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