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Theophylline is metabolized extensively in the liver. [2] It undergoes N-demethylation via cytochrome P450 1A2. It is metabolized by parallel first order and Michaelis-Menten pathways. Metabolism may become saturated (non-linear), even within the therapeutic range. Small dose increases may result in disproportionately large increases in serum ...
[16] [17] [18] Combinations of theophylline, ephedrine, and a barbiturate were later phased out in favor of combinations of theophylline and ephedrine alone (e.g., brand name Franol). [ 2 ] [ 1 ] Fixed-dose combinations of theophylline and ephedrine were abandoned after the 1970s as they did not allow for dose titration in asthma therapy owing ...
[3] [4] [5] However, at high dose, it may lead to cardiac arrhythmias, hypertension, seizures or other serious cardiovascular and/or central nervous system adverse effects. [ 6 ] [ 7 ] [ 8 ] Tedral is contraindicated in individuals with hypersensitivity to theophylline, ephedrine and/or phenobarbital.
The therapeutic window (or pharmaceutical window) of a drug is the range of drug dosages which can treat disease effectively without having toxic effects. [19] Medication with a small therapeutic window must be administered with care and control, frequently measuring blood concentration of the drug, to avoid harm.
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Gabapentin at a low dose of 100 mg has a T max (time to peak levels) of approximately 1.7 hours, while the T max increases to 3 to 4 hours at higher doses. [1] The T max of pregabalin is generally less than or equal to 1 hour at doses of 300 mg or less. [ 1 ]
Gabapentin at a low dose of 100 mg has a T max (time to peak levels) of approximately 1.7 hours, while the T max increases to 3 to 4 hours at higher doses. [83] Food does not significantly affect the T max of gabapentin and increases the C max and area-under-curve levels of gabapentin by approximately 10%.
Fast food gets a bad rap for being unhealthy, but there are healthy fast food options at chains like McDonald’s, Pizza Hut, and Sonic. Dietitians explain.
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