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  2. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    The therapeutic window (or pharmaceutical window) of a drug is the range of drug dosages which can treat disease effectively without having toxic effects. [19] Medication with a small therapeutic window must be administered with care and control, frequently measuring blood concentration of the drug, to avoid harm.

  3. Theophylline/ephedrine - Wikipedia

    en.wikipedia.org/wiki/Theophylline/ephedrine

    [16] [17] [18] Combinations of theophylline, ephedrine, and a barbiturate were later phased out in favor of combinations of theophylline and ephedrine alone (e.g., brand name Franol). [ 2 ] [ 1 ] Fixed-dose combinations of theophylline and ephedrine were abandoned after the 1970s as they did not allow for dose titration in asthma therapy owing ...

  4. Gabapentinoid - Wikipedia

    en.wikipedia.org/wiki/Gabapentinoid

    However, it would appear to be at least 63% at a single dose of 250 mg, based on the fact that this fraction of phenibut was recovered from the urine unchanged in healthy volunteers administered this dose. [31] Gabapentin at a low dose of 100 mg has a T max (time to peak levels) of approximately 1.7 hours, while the T max increases to 3 to 4 ...

  5. Theophylline - Wikipedia

    en.wikipedia.org/wiki/Theophylline

    Theophylline extended-release tablets in Japan. Theophylline, also known as 1,3-dimethylxanthine, is a drug that inhibits phosphodiesterase and blocks adenosine receptors. [1] It is used to treat chronic obstructive pulmonary disease (COPD) and asthma. [2] Its pharmacology is similar to other methylxanthine drugs (e.g., theobromine and caffeine ...

  6. Gabapentin - Wikipedia

    en.wikipedia.org/wiki/Gabapentin

    Gabapentin at a low dose of 100 mg has a T max (time to peak levels) of approximately 1.7 hours, while the T max increases to 3 to 4 hours at higher doses. [83] Food does not significantly affect the T max of gabapentin and increases the C max and area-under-curve levels of gabapentin by approximately 10%. [90]

  7. Calcium channel blocker toxicity - Wikipedia

    en.wikipedia.org/wiki/Calcium_channel_blocker...

    Along with beta blockers and digoxin, calcium channel blockers have one of the highest rates of death in overdose. [2] These medications first became available in the 1970s and 1980s. [ 2 ] They are one of the few types of medication in which one pill can result in the death of a child.

  8. Tricyclic antidepressant overdose - Wikipedia

    en.wikipedia.org/wiki/Tricyclic_antidepressant...

    TCA overdose may occur by accident or purposefully in an attempt to cause death. [2] The toxic dose depends on the specific TCA. [2] Most are non-toxic at less than 5 mg/kg except for desipramine, nortriptyline, and trimipramine, which are generally non-toxic at less than 2.5 mg/kg. [5] [2] In small children one or two pills can be fatal. [6]

  9. Pregabalin - Wikipedia

    en.wikipedia.org/wiki/Pregabalin

    When pregabalin is taken at high doses over a long period of time, addiction may occur, but if taken at usual doses the risk is low. [4] Use during pregnancy or breastfeeding is of unclear safety. [30] Pregabalin was approved for medical use in the United States in 2004. [13] It was developed as a successor to the related gabapentin. [31]

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