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Eosinophils are also involved in many other biological processes, including postpubertal mammary gland development, oestrus cycling, allograft rejection and neoplasia. [21] They have also been implicated in antigen presentation to T cells. [22] Eosinophils are responsible for tissue damage and inflammation in many diseases, including asthma.
PRG2 is a 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro. The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, and activates neutrophils and alveolar macrophages.
Given that eosinophils are the primary IL-5Rα-expressing cells, it is not surprising that this cell type responds to IL-5. In fact, IL-5 was originally discovered as an eosinophil colony-stimulating factor, [ 18 ] is a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to ...
Eosinophil cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. [4] In humans, the eosinophil cationic protein is encoded by the RNASE3 gene. [5] ECP is released during degranulation of eosinophils. This protein is related to inflammation and asthma because in these cases, there are ...
Eosinophils usually account for less than 7% of the circulating leukocytes. [1] A marked increase in non-blood tissue eosinophil count noticed upon histopathologic examination is diagnostic for tissue eosinophilia. [2] Several causes are known, with the most common being some form of allergic reaction or parasitic infection.
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The number of granules in an eosinophil can vary because they have a tendency to degranulate while in the blood stream. [17] Eosinophils play a crucial part in the killing of parasites (e.g., enteric nematodes) because their granules contain a unique, toxic basic protein and cationic protein (e.g., cathepsin [ 14 ] ); [ 18 ] receptors that bind ...
As luck would have it, “a structure in the brain called the dorsal raphe nucleus is strongly activated in orgasm, and that region is very much associated with production and distribution of ...