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Pyoderma gangrenosum. There are two main types of pyoderma gangrenosum: [1] the 'typical' ulcerative form, which occurs in the legs; an 'atypical' form that is more superficial and occurs in the hands and other parts of the body; Other variations are: [4] Peristomal pyoderma gangrenosum comprises 15% of all cases of pyoderma; Bullous pyoderma ...
Pyoderma gangrenosum is variably expressed, which means that it is not always present in all individuals with the disease. It presents as poorly healing ulcers with undermined edges. Pathergy is an important feature (this term refers to the tendency of ulcers to arise at points of injury).
Pyoderma means any skin disease that is pyogenic (has pus). These include superficial bacterial infections such as impetigo , impetigo contagiosa , ecthyma , folliculitis , Bockhart's impetigo , furuncle , carbuncle , tropical ulcer , etc. [ 1 ] [ 2 ] Autoimmune conditions include pyoderma gangrenosum .
The inflammation and ulceration that occurs as a result of pathergy in pyoderma gangrenosum often responds to systemic steroid therapy. The pathergy reaction is a unique feature of Behçet's disease and, according to the International Study Group for Behcet's Disease, is among the major criteria required for the diagnosis.
Pyoderma gangrenosum is a less common skin problem, occurring in under 2%, [69] and is typically a painful ulcerating nodule. [68] [51] Clubbing, a deformity of the ends of the fingers, may also be a result of Crohn's disease. [70] [71]
Ecthyma gangrenosum is a type of skin lesion characterized by vesicles or blisters, which rapidly evolve into pustules and necrotic ulcers with undermined tender erythematous border. " Ecthyma " means a pus-forming infection of the skin with an ulcer, "gangrenosum" refers to the accompanying gangrene or necrosis.
In superficial granulomatous pyoderma, ulcers typically have a clean base and vegetating borders, making them more superficial. Unlike pyoderma gangrenosum, superficial granulomatous pyoderma is more frequently associated with truncal involvement and is not always linked to underlying systemic disease.
A similar response occurs in pyoderma gangrenosum and Behcet's syndrome, and is referred to as pathergy. [3] Rarely Koebner phenomenon has been reported as a mechanism of acute myeloid leukemia dissemination. [4] Warts and molluscum contagiosum are often listed as causing a Koebner reaction, but this is by direct inoculation of viral particles. [3]