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The BNF for Children developed from the British National Formulary (BNF), which prior to 2005 had provided information on the treatment of children, with the doses largely determined by calculations based on the body weight of the child. The guidance was provided by pharmacists and doctors whose expertise was in the care of adults.
The Leffler formula is used for children 0–10 years of age. [1] In those less than a year old, it is = + and for those 1–10 years old, it is = + where m is the number of kilograms the child weighs and a m and a y respectively are the number of months or years old the child is.
The British National Formulary for Children (BNFC) [1] [19] [20] book, first published September 2005, [2] is published yearly, [2] and details the doses and uses of medicines in children from neonates to adolescents. [1]
[1] [2] The degree of circularity of an ellipse is quantified by eccentricity, with values between 0 to 1, where 0 is a perfect circle (waist circumference same as height) and 1 is a vertical line. [1] To accommodate human shape data in a greater range, Thomas and colleagues mapped eccentricity in a range of 1 to 20 by using the equation: [1]
There was an average BSA of 1.73 m 2 for 3,000 cancer patients from 1990 to 1998 in a European Organisation for Research and Treatment of Cancer (EORTC) database. [19] During 2005 there was an average BSA of 1.79 m 2 for 3,613 adult cancer patients in the UK. Among them the average BSA for men was 1.91 m 2 and for women was 1.71 m 2. [20]
Cross-sectional studies in many different global populations have supported the premise that WHtR is a simple and effective anthropometric index to identify health risks in adults of all ages, [20] [21] [25] [26] and in children and adolescents. [27] [28] [29]
The BNF has opposed many public-health interventions that might harm food-industry profits, often using tobacco-industry techniques, such as creating unwarranted doubt and uncertainty around the scientific evidence. [6] In 2023, the BNF had an income of £1.5million, with an expenditure of £1.6million. £0.113million were spent on fundraising. [1]
The WHO Model List of Essential Medicines for Children (aka Essential Medicines List for Children [1] or EMLc [1]), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe in children up to twelve years of age to meet the most important needs in a health system.
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