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Intramuscular injections began to be used for administration of vaccines for diphtheria in 1923, whooping cough in 1926, and tetanus in 1927. [30] By the 1970s, researchers and instructors began forming guidance on injection site and technique to reduce the risk of injection complications and side effects such as pain. [8]
A depot injection, also known as a long-acting injectable (LAI), is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication.
Therapists may use myotherapy (deep pressure as in Bonnie Prudden's approach, massage or tapotement as in Dr. Griner's approach), mechanical vibration, pulsed ultrasound, electrostimulation, [15] ischemic compression, trigger-point-injection (see below), dry-needling, "spray-and-stretch" using a cooling spray (vapocoolant), low-level laser ...
Ultrasound-guided injections are the gold standard for differentiating deep gluteal syndrome from other sources of pain. [9] Diagnostic injections function in a similar way to deep palpation. While palpation causes a signal to be sent along a nerve which patients can localize relative to their pain (the spot hurts or it doesn't), anesthetics ...
After injection, a medication may be designed to be released slowly, called a depot injection, which can produce long-lasting effects. An injection necessarily causes a small puncture wound to the body, and thus may cause localized pain or infection. The occurrence of these side effects varies based on injection location, the substance injected ...
Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion. A subcutaneous injection is administered as a bolus into the subcutis, the layer of skin directly below the dermis and epidermis, collectively referred to as the cutis. The instruments are usually a hypodermic needle and a syringe.
Clopixol Depot: Typical: Viscoleo b: 50–800 mg/2–4 weeks: 4–9 days? 11–21 days: 7.5–9.0: Note: All by intramuscular injection. Footnotes: a = Microcrystalline or nanocrystalline aqueous suspension. b = Low-viscosity vegetable oil (specifically fractionated coconut oil with medium-chain triglycerides). c = Predicted, from PubChem and ...
Targeted drug delivery is the delivery of a drug to its target site without having an effect on other tissues. [22] Interest in targeted drug delivery has grown drastically due to its potential implications in the treatment of cancers and other chronic diseases.