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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [ 8 ] [ 9 ] It may also be used for hiccups and muscle spasms near the end of life, [ 9 ] and off-label to treat alcohol use disorder [ 10 ] [ 11 ] or opioid withdrawal symptoms. [ 12 ]
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Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication.
In 2008, Ameisen wrote a best-selling book, The End Of My Addiction, published in France as Le Dernier Verre (The Last Glass), describing his experience of curing his alcoholism with baclofen. [6] In 2007, an Italian team also showed the effectiveness and the safety of baclofen as a treatment for alcohol addiction. [7]
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Arbaclofen placarbil (/ ɑːr ˈ b æ k l oʊ f ɛ n p l ə ˈ k ɑːr b ɪ l / ar-BAK-loh-fen plə-KAR-bil, also known as XP19986) is a prodrug of R-baclofen.Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels.
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