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Glutethimide is a hypnotic sedative that was introduced by Ciba [3] in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similar withdrawal symptoms.
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Rogletimide, also known as pyridoglutethimide, is a medication which was never marketed. [1] It is related in chemical structure to the sedative/hypnotic drug glutethimide, but instead has pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide and has no significant sedative-hypnotic effect. [2]
Pyrithyldione [1] (Presidon, Persedon) is a psychoactive drug invented in 1949. [2] An improved method of manufacture was patented by Roche in 1959. [3] It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates. [4]
Aminoglutethimide (AG), sold under the brand names Elipten, Cytadren, and Orimeten among others, is a medication which has been used in the treatment of seizures, Cushing's syndrome, breast cancer, and prostate cancer, among other indications.
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γ-Butyrolactone (GBL) or gamma-butyrolactone is an organic compound with the formula O=CO(CH 2) 3.It is a hygroscopic, colorless, water-miscible liquid with a weak characteristic odor.