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NV-5138 works by binding to and modulating sestrin2, a cellular sensor protein for the amino acid leucine, which is a natural activator of mammalian target of rapamycin complex 1 (mTORC1) signaling pathway.
2735 14632 Ensembl ENSG00000111087 ENSMUSG00000025407 UniProt P08151 P47806 RefSeq (mRNA) NM_001160045 NM_001167609 NM_005269 NM_010296 RefSeq (protein) NP_001153517 NP_001161081 NP_005260 NP_034426 Location (UCSC) Chr 12: 57.46 – 57.47 Mb Chr 10: 127.17 – 127.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Zinc finger protein GLI1 also known as glioma-associated oncogene is a ...
[2] [3] [4] The activity of activators is controlled by the ability of the activator to bind to its regulatory site along the DNA. [2] [3] [4] The DNA-binding domain of the activator has an active form and an inactive form, which are controlled by the binding of molecules known as allosteric effectors to the allosteric site of the activator. [4]
PCSX supports network play and external plugins as used by ePSXe.As with many modern emulators, PCSX-Reloaded supports savestates and also has Save Rewind feature (currently only OSX and Linux version), Support for ECM files (currently only OS X and Linux version), Support for Libarchive (currently only OSX and Linux version), widescreen hack and makes use of plug-ins to emulate GPU, SPU, and ...
PPAR-α is primarily activated through ligand binding. Endogenous ligands include fatty acids such as arachidonic acid as well as other polyunsaturated fatty acids and various fatty acid-derived compounds such as certain members of the 15-hydroxyeicosatetraenoic acid family of arachidonic acid metabolites, e.g. 15(S)-HETE, 15(R)-HETE, and 15(S)-HpETE and 13-hydroxyoctadecadienoic acid, a ...
IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. [8] [9] In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40.
12224 Ensembl ENSG00000102554 ENSMUSG00000005148 UniProt Q13887 Q9Z0Z7 RefSeq (mRNA) NM_001730 NM_001286818 NM_009769 RefSeq (protein) NP_001273747 NP_001721 NP_033899 Location (UCSC) Chr 13: 73.05 – 73.08 Mb Chr 14: 99.54 – 99.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene. Function This gene ...
Forkhead box protein J1 is a protein that in humans is encoded by the FOXJ1 gene. [5] It is a member of the Forkhead/winged helix family of transcription factors that is involved in ciliogenesis. [6] FOXJ1 is expressed in ciliated cells of the lung, [7] choroid plexus, [8] reproductive tract, [9] embryonic kidney and pre-somite embryo stage. [10]