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In general, proton pump inhibitors are well tolerated, and the incidence of short-term adverse effects is relatively low. The range and occurrence of adverse effects are similar for all of the PPIs, though they have been reported more frequently with omeprazole. This may be due to its longer availability and, hence, clinical experience.
Pancreatic cancer rarely occurs before the age of 40, and more than half of cases of pancreatic adenocarcinoma occur in those over 70. [2] Risk factors for pancreatic cancer include tobacco smoking, obesity, diabetes, and certain rare genetic conditions. [2] About 25% of cases are linked to smoking, [3] and 5–10% are linked to inherited genes ...
Long-term use of PPIs is strongly associated with the development of benign polyps from fundic glands (which is distinct from fundic gland polyposis); these polyps do not cause cancer and resolve when PPIs are discontinued. No association is seen between PPI use and cancer, but use of PPIs may mask gastric cancers or other serious gastric ...
Pancreatic islet cell tumors are today the major cause of death in persons with MEN-1. Tumors occur in 60-80% of persons with MEN-1 and they are usually multicentric. Multiple adenomas or diffuse islet cell hyperplasia commonly occurs. About 30% of tumors are malignant and have local or distant metastases. [5]
Gastrinoma is the second most common functional pancreatic neuroendocrine tumor (pNET), with a yearly incidence of approximately 0.5 to 21.5 cases per a million of people worldwide. [5] Gastrinomas are located predominantly in the duodenum (70%) and pancreas (25%). [20]
Each year, more than 50,000 people in the U.S. die from pancreatic cancer, making it the fourth-leading cause of cancer deaths in the U.S., per the National Cancer Institute.
A pancreatic tumor is an abnormal growth in the pancreas. [1] In adults, almost 90% are pancreatic cancer and a few are benign. [1] Pancreatic tumors are rare in children. [1] Classification is based on cellular differentiation (ductal, acinar, neuroendocrine, other) and gross appearance (intraductal, cystic, solid). [1]
Colorectal cancer: 13.9 Liver cancer and bile duct cancer: 6.6 Gallbladder cancer: 0.6 Pancreatic cancer: 11.0 Laryngeal cancer: 1.0 Lung cancer: 40.2 Tracheal cancer (including other respiratory organs) 0.1 Bone cancer (including joint cancer) 0.5 Skin cancer (excluding basal and squamous) 3.4 Breast cancer (non-in situ) 11.3 Uterine cancer ...