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Smallpox is the first disease, and so far the only infectious disease of humans, to be eradicated by deliberate intervention. [6] It became the first disease for which there was an effective vaccine in 1798 when Edward Jenner showed the protective effect of inoculation (vaccination) of humans with material from cowpox lesions. [10]
The smallpox vaccine is used to prevent smallpox infection caused by the variola virus. [10] It is the first vaccine to have been developed against a contagious disease. In 1796, British physician Edward Jenner demonstrated that an infection with the relatively mild cowpox virus conferred immunity against the deadly smallpox virus.
Tecovirimat, sold under the brand name Tpoxx among others, [6] is an antiviral medication with activity against orthopoxviruses such as smallpox and mpox. [4] [7] [8] In 2018 it was the first antipoxviral drug approved in the United States. The drug works by blocking cellular transmission of orthopoxviruses, thus preventing disease. [9]
Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus. [7] [11] The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, [10] making smallpox the only human disease to have been eradicated to date.
This vaccine is a 2 or 3 dose series, depending on the brand of the vaccine, that is given at 2 and 4 months in the 2 dose series and at 2,4 and 6 months in the 3 dose series. Studies show that this vaccine is 85-98% effective against severe rotavirus disease and is 74-87% effective against rotavirus disease of any severity in the first year ...
According to the CDC, monkeypox is closely related to the virus that causes smallpox. Both the CDC and the WHO have published data showing that the smallpox vaccine is 85% effective in preventing ...
Onesimus (late 1600s–1700s [1]) was an African (likely Akan) man who was instrumental in the mitigation of smallpox in Boston, Massachusetts.. He introduced his enslaver, Puritan clergyman Cotton Mather, to the principle and procedure of the variolation method of inoculation, which prevented smallpox and laid the foundation for the development of vaccines.
Both Jynneos and ACAM2000 contain vaccinia virus that is closely related to, but less harmful than the viruses that cause smallpox and mpox. ACAM2000 uses a live, infectious form of the vaccinia ...