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Caspar-Klug theory has played an important part in shaping the subsequent study of viruses and other macromolecular assemblies. The original concept was based mainly on electron microscope studies, and has now been refined to take account of the atomic resolution structure of viruses , and other details of protein–protein interactions that ...
Together with D. Caspar he developed a general theory of spherical shells built up of a regular array of asymmetric particles. Klug and his collaborators verified the theory by x-ray and electron microscope studies, thereby revealing new and hitherto unsuspected features of virus structure.
Thus, an icosahedral virus is made of 60N protein subunits. The number and arrangement of capsomeres in an icosahedral capsid can be classified using the "quasi-equivalence principle" proposed by Donald Caspar and Aaron Klug. [13] Like the Goldberg polyhedra, an icosahedral structure can be regarded as being constructed from pentamers and hexamers.
The Caspar-Klug theory of viral capsids This page was last edited on 20 December 2017, at 15:49 (UTC). Text is available under the Creative Commons Attribution ...
Virus crystallisation is the re-arrangement of viral components into solid crystal particles. [1] The crystals are composed of thousands of inactive forms of a particular virus arranged in the shape of a prism. [2] The inactive nature of virus crystals provide advantages for immunologists to effectively analyze the structure and function behind ...
Caspar and Klug were the first to publish the most general correct construction of a geodesic polyhedron, making the name "Goldberg–Coxeter construction" an instance of Stigler's law of eponymy. [12] The discovery of Buckminsterfullerene in 1985 motivated research into other molecules with the structure of a Goldberg polyhedron.
Donald Caspar — theory of quasi-equivalence in icosahedral viruses; ... Aaron Klug (British, 1926 ... and of many viruses including the common cold virus. ...
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