Ad
related to: lactic acidosis metformin wikipediainfo.diatribe.org has been visited by 10K+ users in the past month
Search results
Results from the WOW.Com Content Network
Lactic acidosis refers to the process leading to the production of lactate by anaerobic metabolism. It increases hydrogen ion concentration tending to the state of acidemia or low pH. The result can be detected with high levels of lactate and low levels of bicarbonate. This is usually considered the result of illness but also results from ...
Given severely impaired kidney function, clearance of metformin and lactate is reduced, increasing levels of both, and possibly causing lactic acid buildup. Because metformin decreases liver uptake of lactate, any condition that may precipitate lactic acidosis is a contraindication.
The drug metformin can cause lactic acidosis in patients with kidney failure because metformin inhibits the hepatic gluconeogenesis of the Cori cycle, particularly the mitochondrial respiratory chain complex 1. [8] The buildup of lactate and its substrates for lactate production, pyruvate and alanine, lead to excess lactate. [9]
Typical reduction in glycated hemoglobin (A1C) values for Metformin is 1.5–2.0% Metformin (Glucophage) may be the best choice for patients who also have heart failure, [9] but it should be temporarily discontinued before any radiographic procedure involving intravenous iodinated contrast, as patients are at an increased risk of lactic acidosis.
High anion gap metabolic acidosis. High anion gap metabolic acidosis is a form of metabolic acidosis characterized by a high anion gap (a medical value based on the concentrations of ions in a patient's serum). Metabolic acidosis occurs when the body produces too much acid, or when the kidneys are not removing enough acid from the body.
Complications of diabetes are secondary diseases that are a result of elevated blood glucose levels that occur in diabetic patients. These complications can be divided into two types: acute and chronic. Acute complications are complications that develop rapidly and can be exemplified as diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar ...
Lactic acidosis A buildup of lactic acid in the body due to anaerobic use of glucose as a fuel. It is normal when exercising beyond your aerobic capacity and recovery is rapid and complete, as the lactic acid is oxidized as fuel when oxygen becomes available (generally after a period of deep breathing). Lactose
Definition of lactic acidosis[edit] Definition stated in this wiki article is: lactate levels >5 mmol/L and serum pH <7.35. Lactic acidosis is in Soyoral at al. 2011 defined as a blood pH less than 7.35 and a serumlactate more than 2mmol/L. I havent checked it up, just wanted to point that out.
Ad
related to: lactic acidosis metformin wikipediainfo.diatribe.org has been visited by 10K+ users in the past month