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Ball-and-stick model of cimetidine, the prototypical H 2 receptor antagonist. H2 antagonists, sometimes referred to as H2RAs [1] and also called H2 blockers, are a class of medications that block the action of histamine at the histamine H 2 receptors of the parietal cells in the stomach. This decreases the production of stomach acid.
Cimetidine is widely distributed throughout all tissues. [7] It is able to cross the blood–brain barrier and can produce effects in the central nervous system (e.g., headaches, dizziness, somnolence ). [2] The volume of distribution of cimetidine is 0.8 L/kg in adults and 1.2 to 2.1 L/kg in children. [6]
The Generic Product Identifier ( GPI) is a 14-character hierarchical classification system created by Wolters Kluwer's Medi-Span that identifies drugs from their primary therapeutic use down to the unique interchangeable product regardless of manufacturer or package size. The code consists of seven subsets, each providing increasingly more ...
The national drug code is a unique 10 or 11 digit, 3-segment numeric identifier assigned to each medication listed under Section 510 of the US Federal Food, Drug, and Cosmetic Act. The segments identify the labeler or vendor, product (within the scope of the labeler), and trade package (of this product). The first segment, the labeler code, is ...
Fexofenadine, sold under the brand name Allegraamong others,[10]is an antihistaminepharmaceutical drugused in the treatment of allergy symptoms, such as hay feverand urticaria. [11] Therapeutically, fexofenadine is a selectiveperipheralH1blocker.
Hydroxyzine, sold under the brand names Ataraxand Vistarilamong others, is an antihistaminemedication.[8] It is used in the treatment of itchiness, insomnia, anxiety, and nausea, including that due to motion sickness.[8] It is used either by mouthor injection into a muscle. [8]
The histamine receptor H 2 belongs to the rhodopsin-like family of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. [6]
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