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The protein encoded by this gene is a key licensing factor in the assembly of pre-replication complexes (pre-RC), which occurs during the G1 phase of the cell cycle. In the assembly of pre-RCs, origin recognition complexes (ORC1-6) recognize and bind to DNA replication origins.
Fig. 1 The diagram shows the role of Cdk1 in progression through the S. cerevisiae cell cycle. Cln3-Cdk1 leads to Cln1,2-Cdk1 activity, eventually resulting in Clb5,6-Cdk1 activity and then Clb1-4-Cdk1 activity. [5] When bound to its cyclin partners, Cdk1 phosphorylation leads to cell cycle progression.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells.
Cycle (cyc) is a gene in Drosophila melanogaster that encodes the CYCLE protein (CYC). The Cycle gene ( c yc) is expressed in a variety of cell types in a circadian manner. It is involved in controlling both the sleep-wake cycle and circadian regulation of gene expression by promoting transcription in a negative feedback mechanism.
66953 Ensembl ENSG00000144354 ENSMUSG00000055612 UniProt Q9BWT1 Q9D0M2 RefSeq (mRNA) NM_031942 NM_145810 NM_025866 RefSeq (protein) NP_114148 NP_665809 NP_080142 Location (UCSC) Chr 2: 173.35 – 173.37 Mb Chr 2: 72.31 – 72.32 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cell division cycle-associated protein 7 is a protein that in humans is encoded by the CDCA7 gene. This gene ...
Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. [5] [6] [7] The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. [8] The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 ...
Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. [5] [6] Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. [7]
CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. [5] [6] [7] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins. [8] CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell ...