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Tizanidine, sold under the brand name Zanaflex among others, is an alpha-2 (α 2) adrenergic receptor agonist, [2] similar to clonidine, that is used to treat muscle spasticity due to spinal cord injury, multiple sclerosis, and spastic cerebral palsy. [3] Effectiveness appears similar to baclofen or diazepam. [4] It is taken by mouth. [5]
Tizanidine was found to decrease the average frequency of headaches per week, the headache intensity, and the mean headache duration. [15] Through studies, Fluoxetine resulted in better mood ratings and "significant increases in headache-free days". [16]
Tizanidine is perhaps the most thoroughly studied clonidine analog, and is an agonist at α 2-adrenergic receptors, but reduces spasticity at doses that result in significantly less hypotension than clonidine. [26]
Acorda Therapeutics Reports Third Quarter 2012 Financial Results AMPYRA® (dalfampridine) Third Quarter Net Revenue of $69.8 Million Combined Third Quarter ZANAFLEX Franchise and ex-U.S. FAMPYRA ...
The company licensed tizanidine (Zanaflex) from Élan in the early 2000s to help meeting cash flow goals. [2] Acorda sells both capsule and tablet forms of this drug, with emphasis on the capsule form as this has patent protection through 2021, while the tablet form has many generic competitors. [2]
Tizanidine; Methyldopa; Methylnorepinephrine; Norepinephrine [6] -3-nitrobiphenyline is an α 2C selective agonist as well as being a weak antagonist at the α 2A and α 2B subtypes. [7] [8] amitraz [9] Detomidine [citation needed] Lofexidine, an α 2A adrenergic receptor agonist. [10] Medetomidine, an α2 adrenergic agonist. [11]
The first over-the-counter birth control pill will be available in U.S. stores later this month, allowing American women and teens to purchase contraceptive medication as easily as they buy aspirin.
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS) and are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling.
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