Search results
Results from the WOW.Com Content Network
Long-term or habitual use can lead to severe neurological damage. [3] Nitrous oxide is said to enhance the effects of psychedelics. [6] Since nitrous oxide can cause dizziness, dissociation, and temporary loss of motor control, it is unsafe to inhale while standing up. Safer use can involve inhalation while seated to decrease risks of injury by ...
Nitrous oxide is neurotoxic, and medium or long-term habitual consumption of significant quantities can cause neurological harm with the potential for permanent damage if left untreated. [104] [103] It is believed that, like other NMDA receptor antagonists, N 2 O produces Olney's lesions in rodents upon prolonged (several hour) exposure.
In 1911, the anaesthetist Arthur Ernest Guedel first described the use of self-administration of a nitrous oxide and oxygen mix. It was not until 1961 that the first paper was published by Michael Tunstall and others, describing the administration of a pre-mixed 50:50 nitrous oxide and oxygen mix, which led to the commercialisation of the product.
Many teens inhale nitrous oxide to feel its euphoric effects. "When enough of the drug is ingested, it can cause a short-lived high, numbness and a sense of joy or laughter," explains Mishra.
Nitrous oxide is thought to be particularly non-toxic, though heavy long-term use can lead to a variety of serious health problems linked to the destruction of vitamin B12 and folic acid. [17] [18] Nitrous oxide "whippets" are small aerosol containers designed for charging whipped cream dispensers.
The effects of dissociatives can include sensory dissociation, hallucinations, mania, catalepsy, analgesia and amnesia. [ 4 ] [ 5 ] [ 6 ] According to Pender (1972), "the state has been designated as dissociative anesthesia since the patient truly seems disassociated from his environment."
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!
In some cases the level or exposure-time may be critical, with some substances only becoming neurotoxic in certain doses or time periods. Some of the most common naturally occurring brain toxins that lead to neurotoxicity as a result of long term drug use are amyloid beta (Aβ), glutamate, dopamine, and oxygen radicals.