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Individuals affected by RS3PE typically have repeated episodes of inflammation of the lining of their synovial joints and swelling of the end portion of the limbs. [8] The arms and hands are more commonly affected than the legs and feet. [8] Both sides are usually involved though RS3PE can affect only one side in certain cases. [8]
What it looks like: Purplish lesions on the inner arms, legs, wrists, or ankles can signify lichen planus, a skin rash triggered by an overreaction of the immune system.
Angioedema is an area of swelling of the lower layer of skin and tissue just under the skin or mucous membranes. [1] [3] The swelling may occur in the face, tongue, larynx, abdomen, or arms and legs. [1] Often it is associated with hives, which are swelling within the upper skin. [1] [3] Onset is typically over minutes to hours. [1]
Edema (American English), also spelled oedema (British English), and also known as fluid retention, dropsy and hydropsy, is the build-up of fluid in the body's tissue, [1] a type of swelling. [4] Most commonly, the legs or arms are affected. [1] Symptoms may include skin that feels tight, the area feeling heavy, and joint stiffness. [1]
The wrist sign (Walker-Murdoch sign) is elicited by asking the person to curl the thumb and fingers of one hand around the other wrist. A positive wrist sign is where the little finger and the thumb overlap, caused by a combination of thin wrists and long fingers.
Leg edema Peripheral edema is edema (accumulation of fluid causing swelling) in tissues perfused by the peripheral vascular system , usually in the lower limbs . In the most dependent parts of the body (those hanging distally ), it may be called dependent edema.
In cases of swelling, the extremities' circumference is measured over time for reference. In early stages of lymphedema, elevating the limb may reduce or eliminate the swelling. Palpation of the wrist or ankle can determine the degree of swelling; assessment includes a check of the pulses.
Fat deposits/swelling in legs and arms not in hands or feet; hands and feet may be affected as the disease progresses. Fat deposits / swelling widespread in legs/arms/torso: Fat deposits/swelling in one limb including hands and feet: Fat deposits widespread Swelling near ankles; brownish discoloration of lower legs (hemosiderin deposits).